Week 5 brings a full board from Thursday to Saturday. Lines and totals below come from the odds list you shared. Games include Penn State vs Oregon, Georgia vs Alabama, LSU vs Ole Miss, Notre Dame vs Arkansas, Ohio State vs Washington, USC vs Illinois, and more.
If you run a book, this is a good slate to keep players engaged all weekend. Use tools and reports at WagerHome to set limits, tweak menus, and track risk as lines move.
Notre Dame vs Arkansas (Saturday) – Line: Arkansas +6, Total 64.5
Notre Dame started 0–2 but beat Purdue last week. Depending on the number used in the Purdue game, the Irish could be 0–3 against the line this season. They have gone Over in five straight and nine of 12 since late 2024.
Arkansas opened 2–0, then dropped close games to Ole Miss and Memphis in Weeks 3 and 4. The Hogs are on a 7–3 Over run since late 2024 and went 6–3 against the spread as underdogs last season. Pace and big plays point to points here.
Pick: Over 64.5; Notre Dame 35, Arkansas 31
Oregon vs Penn State (Saturday) – Line: Penn State -3.5, Total 52.5
Penn State is laying a field goal and a hook. The Nittany Lions want balance and a steady run game to stay on schedule. If they get early leads, they tend to lean on defense and shorten the game.
Oregon can stretch the field and run tempo. The Ducks will test Penn State’s corners and try to hit explosives. Key is third-down defense against Oregon’s quick game.
Pick: Penn State -3.5; Penn State 27, Oregon 21
Alabama vs Georgia (Saturday) – Line: Georgia -3, Total 53.5
Georgia is favored by a field goal. The Bulldogs lean on a strong front and efficient passing on early downs. If they avoid long-yardage spots, they can protect the ball and play field position.
Alabama needs steady QB play and a clean pocket. Explosive runs would help to keep Georgia honest. Special teams and short fields could swing this one.
Pick: Georgia -3; Georgia 27, Alabama 20
LSU vs Ole Miss (Saturday) – Line: Ole Miss -2, Total 55.5
Ole Miss is a small favorite at home. The Rebels want tempo and rhythm throws to set up shots. A quick start would force LSU into more man coverage and open the middle of the field.
LSU needs stops on early downs to get Ole Miss behind the chains. Red-zone defense is the swing area. If LSU holds to threes, they’re live late.
Pick: Ole Miss -2; Ole Miss 31, LSU 27
Ohio State vs Washington (Saturday) – Line: Washington +8.5, Total 52.5
Ohio State is more than a touchdown favorite. The Buckeyes lean on a top unit at receiver and a deep backfield. If they build a lead, the pass rush can take over.
Washington will try to spread the field and hit quick reads. Keeping third downs short is key. If Washington avoids negative plays, the +8.5 becomes valuable.
Pick: Washington +8.5; Ohio State 28, Washington 23
USC vs Illinois (Saturday) – Line: Illinois +6.5, Total 59.5
USC will throw often and play fast. They need protection and fewer empty trips in the red zone. If the run game shows up, it opens deep posts and seams.
Illinois wants long drives and to slow the game. If they keep USC under 10 possessions, the +6.5 matters. Look for Illinois to lean on short passes and QB runs on third-and-medium.
Pick: Illinois +6.5; USC 31, Illinois 27
Utah vs West Virginia (Saturday) – Line: West Virginia +10.5, Total 49.5
Utah’s edge is in the trenches and on defense. If they control the line, they can shorten the game and grind clock. That points to a lower total script.
West Virginia’s path is explosive plays and field position. If they can hit a couple of shot plays and avoid turnovers, the +10.5 can cash. Expect a conservative approach early.
Pick: West Virginia +10.5; Utah 24, West Virginia 17
Baylor vs Oklahoma State (Saturday) – Line: Baylor +20.5, Total 59.5
Oklahoma State is a big favorite. The Cowboys can score in bunches when the pass game is synced. If they reach 35+, the spread becomes reachable late.
Baylor needs to slow tempo and stay within two scores into the fourth. Field goals over touchdowns will not be enough. Backdoor potential exists with a late drive.
Pick: Baylor +20.5; Oklahoma State 38, Baylor 21
Indiana vs Iowa (Saturday) – Line: (Board shows +7.5, Total 48.5)
This sets up as a field-position game. Iowa wants defense, punts inside the 10, and short fields for the offense. That script leans to the Under.
Indiana must avoid turnovers and quick three-and-outs. If they can reach 17 points, the spread becomes tight. First to 20 might win.
Pick: Under 48.5; Iowa 23, Indiana 17
Auburn vs Texas A&M (Saturday) – Line: Texas A&M -6.5, Total 52.5
Texas A&M is under a touchdown at home. The Aggies need balance and steady third-down offense. If they get stops on early downs, Auburn will face long fields.
Auburn’s best shot is run game and play-action. Limit possessions and keep this close into the fourth. A&M’s depth is the edge late.
Pick: Texas A&M -6.5; Texas A&M 27, Auburn 17
Quick Hits
Florida State vs Virginia (Friday) – Line: Florida State -7, Total 57.5
Florida State has the better athletes on the edge. If the ‘Noles win early downs and protect the ball, they cover the number.
Pick: Florida State -7; Florida State 34, Virginia 24
Army vs East Carolina (Thursday) – Line: East Carolina -3.5, Total 52.5
ECU’s edge is speed in space. Army wants long drives and fourth-and-short tries. If ECU gets two quick scores, Army’s script gets tough.
Pick: East Carolina -3.5; East Carolina 28, Army 20
Week 5 Betting Prediction & Bookie Notes
This board has several tight numbers and a few live underdogs. Best spread looks: Penn State -3.5 vs Oregon, Georgia -3 vs Alabama, and West Virginia +10.5 vs Utah. Totals lean: Notre Dame–Arkansas Over 64.5 and Indiana–Iowa Under 48.5.
If you manage players, use WagerHome to set sharp profiles, offer alt lines, and flag parlays that stack correlated outcomes. With Friday games and a Thursday opener, use staggered limits and keep an eye on late steam. Good luck in Week 5.
Best Card (summary): Penn State -3.5; Georgia -3; Ole Miss -2; Washington +8.5; Illinois +6.5; West Virginia +10.5; Baylor +20.5; Under 48.5 (Indiana–Iowa); Over 64.5 (Notre Dame–Arkansas); Texas A&M -6.5; Florida State -7; East Carolina -3.5.
