Week 5 of the NFL season kicks off Thursday night and closes with a marquee Monday night showdown in Jacksonville. With bye weeks beginning, the slate is lighter but features key divisional clashes, an early London kickoff, and several inter-conference battles. Here’s a look at the odds and quick previews for every matchup.
Thursday Night Football
49ers at Rams (-6.5, 46.5)
Los Angeles has emerged as the early NFC West favorite while San Francisco struggles with injuries on both sides of the ball. Matthew Stafford leads one of the league’s most productive passing offenses, and the Rams opened as field-goal favorites before bettors pushed the line higher.
London Game
Vikings (-3.5) vs. Browns (36.5)
The second straight week of football in London features Minnesota as the favorite. Cleveland’s defense has kept games close, but the offense has lacked consistency. The low total highlights expectations for a defensive battle.
Early Sunday Games
Raiders at Colts (-6.5, 47.5)
Indianapolis has been steady behind a balanced attack, while Las Vegas continues to search for offensive rhythm. The Colts are touchdown favorites at home.
Cowboys (-2.5, 47.5) at Jets
Dallas is a slight road favorite as its defense tries to rebound from recent struggles. The Jets have leaned on their rushing attack, setting up an interesting matchup in East Rutherford.
Broncos at Eagles (-3.5, 43.5)
The line moved toward Denver during the week after opening at -5.5 for Philadelphia. Both teams have been unpredictable, but this sets up as a physical contest.
Dolphins (-1.5, 44.5) at Panthers
Miami is a small favorite on the road, though missing key playmakers on offense could make things difficult. Carolina will look to take advantage of the Dolphins’ shaky run defense.
Texans (-1.5, 39.5) at Ravens
This line flipped from Baltimore favored to Houston laying points after Lamar Jackson’s injury questions. The Texans are still favored by less than a field goal in what could be a low-scoring matchup.
Giants at Saints (-1.5, 40.5)
New Orleans opened as an underdog but is now favored at home. The Giants lost top wideout Malik Nabers for the season, and that injury swung the line in the Saints’ direction.
Late Sunday Games
Titans at Cardinals (-7.5, 41.5)
Arizona has been one of the league’s most reliable teams against non-conference opponents, while Tennessee has struggled badly. The Cardinals are more than a touchdown favorite.
Buccaneers at Seahawks (-3.5, 44.5)
Seattle is favored at home in what looks like one of the more competitive late-window games. Both offenses have shown flashes, but the defenses have kept games close.
Commanders at Chargers (-2.5, 47.5)
The Chargers remain small home favorites, but Washington is expected to get rookie QB Jayden Daniels back. Both teams can score in bunches, which is why the total sits near 48.
Lions (-10.5, 49.5) at Bengals
Detroit is one of the largest favorites of the week against a Cincinnati team still searching for answers on offense. The Lions’ strong offensive line has helped them dominate weaker opponents.
Sunday Night Football
Patriots at Bills (-8.5, 49.5
Buffalo is heavily favored at home in the AFC East matchup. The Patriots’ defense has kept them competitive, but they’ll need to slow Josh Allen and a potent Bills rushing attack to stay close.
Monday Night Football
Chiefs (-3.5, 46.5) at Jaguars
The week closes with Kansas City on the road in Jacksonville. Patrick Mahomes and the Chiefs have been steady if unspectacular, while the Jaguars are looking for a statement win against one of the AFC’s elite.
Bye Week Teams
Falcons, Bears, Packers, Steelers
This Week 5 slate features cross-conference battles, a primetime divisional rivalry, and the first round of byes. From London to Jacksonville, every game carries early-season playoff implications.
