Week 2 of the 2025 college football season kicks off Friday, September 5, and runs through Saturday, September 6. After an eventful opening weekend, bettors now look at fresh matchups with several ranked teams in action. This week includes early conference play, major non-conference meetings, and a few lopsided spreads.
Some of the notable lines include Michigan vs Oklahoma (-5.5), Oregon (-28.5) against Oklahoma State, and Ole Miss (-10) against Kentucky. With early season results fresh in mind, these spreads show where oddsmakers see strength and where bettors may find value. For more betting action and PPH bookie services, check out WagerHome.
Ole Miss vs Kentucky PPH Prediction – Sept 6, 2025
Ole Miss enters Week 2 after a solid start, and this matchup brings revenge from last year’s upset loss to Kentucky. The Rebels are laying -10 on the road with the total at 50.5. Both teams won in Week 1 against non-conference opponents, but SEC play changes the level of competition quickly.
Lane Kiffin’s team is strong against the spread in road games, while Kentucky has struggled to cover since mid-2024. Ole Miss should look to establish the run early and force Kentucky into long-yardage passing downs. Motivation from last year’s defeat could also play a role in this one.
Pick: Ole Miss -10
Michigan vs Oklahoma PPH Prediction – Sept 6, 2025
Michigan and Oklahoma meet in one of the biggest games of the week. The Sooners are -5.5 favorites with the total at 45.5. Both teams are coming off wins in Week 1, but this matchup should be much tighter and will impact the playoff race.
Oklahoma’s offense has shown it can score quickly, while Michigan relies more on defense and ball control. With the spread under a touchdown, oddsmakers are leaning toward Oklahoma’s offensive edge. Expect a lower-scoring battle, and the Sooners may have just enough to cover.
Pick: Oklahoma -5.5
Oregon vs Oklahoma State PPH Prediction – Sept 6, 2025
Oregon is a heavy -28.5 favorite against Oklahoma State with a total set at 57.5. The Ducks rolled in their opener, while Oklahoma State struggled to find consistency. This line shows how big the gap is expected to be between the two programs right now.
Oregon has the firepower to cover large spreads, especially at home, and their defense should limit the Cowboys’ scoring chances. Oklahoma State will need turnovers or special teams help to keep it close. The Ducks are the safer side in this spot.
Pick: Oregon -28.5
Other Week 2 Notable Lines
- James Madison vs Louisville (-13.5, 56.5)
- Iowa vs Iowa State (-3, 41.5)
- SMU vs Baylor (+2.5, 65.5)
- Texas vs San Jose State (-36.5, 52.5)
- LSU vs Louisiana Tech (+37.5, 51.5)
- Alabama vs UL Monroe (+36.5, 50.5)
PPH Betting Prediction
Week 2 provides plenty of betting opportunities with both large spreads and close rivalry games on the board. Ole Miss looks like the sharp side against Kentucky, while Oklahoma and Oregon are strong plays in their matchups. Unders could also be in play for games like Michigan vs Oklahoma given the defensive matchup.
To get the best value on college football betting and to operate as a PPH bookie, WagerHome offers complete sportsbook solutions. Manage lines, take bets, and expand your service with ease at WagerHome.com.
Pick Recap: Ole Miss -10, Oklahoma -5.5, Oregon -28.5
