Week 3 of the 2025 NFL season is here, and bettors have plenty of angles with big lines, close spreads, and divisional battles on the slate. The action starts Thursday night when the Miami Dolphins visit the Buffalo Bills and closes Monday with the Detroit Lions against the Baltimore Ravens.
This week features undefeated showdowns, winless teams searching for answers, and point spreads moving quickly. It’s the perfect time to manage your sheet with WagerHome and get every edge possible.
Thursday Night Football – Miami Dolphins at Buffalo Bills
Odds: Bills -12.5, Total 49.5
Buffalo is 2-0 with a balanced offense and tough defense. Josh Allen has dominated Miami in recent years with 16 TDs and just 3 INTs over his last six games against them. Miami is 0-2 and struggling to protect Tua Tagovailoa, who has nine career picks against the Bills.
Prediction: Bills win 31-17, Buffalo covers.
Sunday Early Slate
New York Jets at Tampa Bay Buccaneers
Odds: Buccaneers -6.5, Total 44.5
The Jets may be without Justin Fields, which hurts their chances to attack a beatable Tampa secondary. Tampa Bay is running the ball well and owns a home-field edge.
Pick: Buccaneers 24-13.
Indianapolis Colts at Tennessee Titans
Odds: Colts -3.5, Total 43.5
Daniel Jones has been sharp in Indy’s new system, but the Titans’ defense matches up well against the pass. Jonathan Taylor and the ground game give the Colts the final push.
Pick: Colts 27-20.
Pittsburgh Steelers at New England Patriots
Odds: Steelers -1.5, Total 44.5
Aaron Rodgers came back to earth in Week 2, and the Steelers’ defense has been poor. The Patriots’ run game with Rhamondre Stevenson and rookie TreVeyon Henderson gives New England the edge at home.
Pick: Patriots 23-20.
Houston Texans at Jacksonville Jaguars
Odds: Jaguars -1.5, Total 43.5
Both teams are 0-2. Trevor Lawrence has thrown three interceptions already, while Houston’s pass rush has been disruptive. Motivation is higher for Houston, but home field leans to Jacksonville.
Pick: Jaguars 21-20.
Green Bay Packers at Cleveland Browns
Odds: Packers -7.5, Total 41.5
Green Bay has combined a strong defense with Jordan Love’s efficient passing. Cleveland gave up 34 to Baltimore last week and may struggle again.
Pick: Packers 28-14.
Sunday Afternoon Slate
Los Angeles Rams at Philadelphia Eagles
Odds: Eagles -3.5, Total 44.5
The Eagles’ balanced attack keeps opponents on the ground while the defense holds steady. The Rams are strong rushing the passer but weaker in the secondary.
Pick: Eagles 26-20.
Atlanta Falcons at Carolina Panthers
Odds: Falcons -5.5, Total 43.5
Atlanta is leaning on the run, with over 30 carries last week. Carolina’s defense ranks near the bottom against planned rushes. Expect the Falcons to control the clock.
Pick: Falcons 23-14.
Denver Broncos at Los Angeles Chargers
Odds: Chargers -2.5, Total 45.5
Justin Herbert is top three in passing yards, and the Chargers’ defense has been strong. Denver’s Bo Nix has been turnover-prone, making this tough on the road.
Pick: Chargers 27-21.
New Orleans Saints at Seattle Seahawks
Odds: Seahawks -7.5, Total 41.5
Seattle just beat Pittsburgh behind a strong run game and turnovers forced. Rookie QB Spencer Rattler faces a tough test at Lumen Field.
Pick: Seahawks 24-16.
Arizona Cardinals at San Francisco 49ers
Odds: 49ers -1.5, Total 44.5
Kyler Murray ranks top 10 in passing EPA. San Francisco leans on Christian McCaffrey and a balanced offense. The home edge gives the 49ers the slight nod.
Pick: 49ers 27-24.
Dallas Cowboys at Chicago Bears
Odds: Cowboys -1.5, Total 49.5
Caleb Williams is struggling with turnovers, and the Bears’ defense just gave up 52 points. Dallas is better suited for a high-scoring game.
Pick: Cowboys 31-24.
Sunday Night Football – Kansas City Chiefs at New York Giants
Odds: Chiefs -6.5, Total 45.5
The Giants are 0-2 and giving up big plays. Kansas City should attack the run game with Isiah Pacheco while Mahomes gets easier throws. Andy Reid’s play-calling edge is too much.
Prediction: Chiefs 30-20, KC covers.
Monday Night Football – Detroit Lions at Baltimore Ravens
Odds: Ravens -4.5, Total 52.5
This is a marquee matchup with both teams among early NFC and AFC favorites. Detroit dropped 52 on Chicago last week. Baltimore has Lamar Jackson at home but has been weak against the run. Jahmyr Gibbs and David Montgomery could find success.
Prediction: Ravens 28-27, but Lions cover.
PPH Betting Prediction
Week 3 has heavy favorites like Buffalo and Green Bay but also tight spreads in spots like Jaguars-Texans and 49ers-Cardinals. The board offers value on underdogs Detroit and New England to cover, while Dallas and Buffalo look strong as chalk plays.
With spreads moving and quarterback injuries creating uncertainty, now is the best time to set up your player sheet with WagerHome. Manage every line, adjust risk, and maximize profits this NFL season.
Best Pick: Buffalo Bills -12.5
