Here’s a full look at the Week 6 NFL odds, spreads, and betting previews for every matchup. All odds are current as of Oct 8, 2025. Use this guide to help manage your own player sheet with WagerHome.
Odds can shift quickly with injuries or weather, so track line movement and adjust your prices as needed. All spreads and totals are from major sportsbooks.
Eagles at Giants (Thursday)
Spread: Eagles -7 | Total: 40.5 | Moneyline: Eagles -360, Giants +285
Preview: Philadelphia’s defense ranks near the top in sacks and run stopping. The Giants will try to run clock and stay close early. If Philly scores first, this game could get away fast.
Broncos vs Jets (London)
Spread: Broncos -7.5 | Total: 43.5 | Moneyline: Broncos -440, Jets +340
Preview: Denver’s balanced offense travels well, while the Jets have struggled with turnovers. The time zone change favors the team with more discipline. Expect a slower start before the Broncos pull away late.
Browns at Steelers
Spread: Steelers -5.5 | Total: 37.5 | Moneyline: Steelers -258, Browns +210
Preview: Aaron Rodgers has brought calm to the Pittsburgh offense. Cleveland’s scoring has dipped to the bottom tier of the league. If the Browns can’t generate turnovers, they’ll struggle to keep this one close.
Cardinals at Colts
Spread: Colts -6.5 | Total: 47.5 | Moneyline: Colts -310, Cardinals +250
Preview: The Colts’ offense is hitting stride behind a strong rushing attack. Arizona’s defense has given up big plays through the air. Indianapolis should control this one if they avoid early turnovers.
Rams at Ravens
Spread: Rams -7.5 | Total: 45.5 | Moneyline: Rams -395, Ravens +310
Preview: Lamar Jackson’s status remains uncertain. Without him, Baltimore leans heavily on the run, which plays into Los Angeles’ strength. The Rams’ passing edge makes them the safer side.
Seahawks at Jaguars
Spread: Jaguars -1.5 | Total: 46.5 | Moneyline: Jaguars -120, Seahawks +100
Preview: This is close to a pick’em. Jacksonville’s defense has been solid at home, while Seattle relies on big passing plays. Whichever team wins third down likely covers the short spread.
Cowboys at Panthers
Spread: Cowboys -3 | Total: 49.5 | Moneyline: Cowboys -180, Panthers +150
Preview: Dak Prescott has eight touchdowns and zero turnovers over the last two games. Carolina ranks near the bottom in sacks and pressure rate. Dallas should find plenty of open lanes on offense.
Chargers at Dolphins
Spread: Chargers -4.5 | Total: 44.5 | Moneyline: Chargers -230, Dolphins +190
Preview: The Chargers have been strong early but shaky late. Miami’s offense has cooled after a fast start to the season. Whichever team wins the turnover margin should take this one.
Patriots at Saints
Spread: Patriots -3.5 | Total: 45.5 | Moneyline: Patriots -185, Saints +154
Preview: New England’s defense continues to play physical and disciplined football. The Saints need to find consistency on third down to stay close. Expect a low-scoring game controlled by field position.
Titans at Raiders
Spread: Raiders -4.5 | Total: 41.5 | Moneyline: Raiders -230, Titans +190
Preview: The Raiders’ offense has shown flashes at home, while the Titans’ run defense has been soft. If Las Vegas protects the football, they should cover this short number at home.
49ers at Buccaneers
Spread: Buccaneers -3 | Total: 47.5 | Moneyline: Buccaneers -155, 49ers +130
Preview: Tampa Bay’s Baker Mayfield has a 10-to-1 touchdown-to-interception ratio. San Francisco ranks last in yards per carry and is struggling to move the ball. The Bucs’ home field and cleaner offense give them the edge.
Bengals at Packers
Spread: Packers -14.5 | Total: 44 | Moneyline: Packers -950, Bengals +625
Preview: Cincinnati traded for Joe Flacco to steady the offense. Green Bay is rolling on both sides of the ball and sits as the biggest favorite of the week. The Packers should win comfortably unless turnovers pile up.
Lions at Chiefs
Spread: Chiefs -2.5 | Total: 52.5 | Moneyline: Chiefs -135, Lions +114
Preview: This is the game of the week. Both offenses rank in the top five in scoring. The winner will likely come down to red-zone efficiency and late-game execution. Expect fireworks Sunday night.
Bills at Falcons (Monday)
Spread: Bills -4.5 | Total: 49.5 | Moneyline: Bills -218, Falcons +180
Preview: Buffalo’s passing game remains dangerous, but Atlanta has played well at home. If the Bills protect Josh Allen, they should pull away. The total leans toward the Over if both teams find rhythm early.
Bears at Commanders (Monday)
Spread: Commanders -4.5 | Total: 50.5 | Moneyline: Commanders -225, Bears +185
Preview: Both defenses have given up big plays in recent weeks. Chicago’s offense can move the ball, but turnovers continue to cost them. Washington’s balanced attack should handle business at home.
PPH Betting Notes
Lines between three and seven points are where most betting action comes in. Manage exposure by balancing sides and totals. Games with totals above 50 often draw Over money, while low totals attract sharp Under play.
Stay ready to adjust juice and spreads throughout the weekend. Run your player sheet with full control and live updates through WagerHome at WagerHome.com.
