The 2025 MLB season kicks off on Thursday, March 27, with 14 games featuring teams from across the league. Two key matchups include the Chicago White Sox facing the Los Angeles Angels and the Cleveland Guardians taking on the Kansas City Royals.
With exciting storylines and new rosters taking shape, Opening Day provides bettors with plenty of options to analyze. Below are previews and betting insights for some of the biggest games. Be sure to check out WagerHome for the latest odds and betting tips.
Chicago White Sox vs Los Angeles Angels PPH Prediction & Picks – March 27, 2025
White Sox Preview – Can Their Pitching Deliver?
The White Sox begin their season at home with Sean Burke on the mound. Burke had a strong spring and will look to provide stability in Chicago’s rotation. Offensively, Luis Robert Jr. leads the charge after hitting 38 home runs last season, and Andrew Vaughn remains a key run producer.
Chicago’s bullpen struggled last season, ranking 27th in ERA. The addition of veteran reliever Joe Kelly aims to provide some late-inning stability. The White Sox must improve their pitching depth to avoid another difficult season.
The lineup features young talent like Colson Montgomery, who had a strong spring and could be a breakout player. With veteran Tim Anderson gone, Montgomery is expected to take on a larger role in the lineup.
Angels Preview – Will the Lineup Produce?
The Angels counter with Yusei Kikuchi as their Opening Day starter. Kikuchi had a strong second half in 2024 and looks to carry that momentum into 2025. He’ll be supported by a lineup that still features Mike Trout and Anthony Rendon.
The Angels added depth in the offseason with the acquisition of Brandon Drury. His power bat adds support to the middle of the order. Jo Adell’s development is another key storyline for Los Angeles as the team looks for consistent outfield production.
The bullpen will be a focus after ranking in the bottom half of the league in 2024. The Angels will rely on Carlos Estévez in the closer role, but additional arms must step up for consistent success.
PPH Betting Prediction
The Angels enter this matchup as slight favorites at -148, while the White Sox are home underdogs at +124. Kikuchi’s recent form gives the Angels the edge, but Chicago’s lineup has enough power to keep things close. Expect a competitive game with a potential for late scoring.
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Pick: Angels -148
Cleveland Guardians vs Kansas City Royals PPH Prediction & Picks – March 27, 2025
Guardians Preview – Young Arms Take the Stage
The Guardians will start Tanner Bibee on Opening Day. Bibee finished last season with a 3.45 ERA and has become one of Cleveland’s most reliable arms. He will be supported by a lineup anchored by José Ramírez, who hit 31 home runs last season.
Steven Kwan remains a key contributor in the leadoff role after finishing 2024 with a .290 average. The Guardians are relying on young players like Brayan Rocchio and Gabriel Arias to improve their offensive production.
Cleveland’s bullpen is a strength with Emmanuel Clase handling closing duties. Clase posted a 1.92 ERA last season and is one of the most reliable closers in baseball.
Royals Preview – Can Kansas City Find Consistency?
Kansas City will counter with Cole Ragans as their Opening Day starter. Ragans had a breakout 2024 season, posting a 3.17 ERA across 28 starts. He’ll need strong run support from Bobby Witt Jr., who hit 33 home runs and stole 45 bases last season.
The Royals’ offense struggled with consistency last season, but Vinnie Pasquantino provides a strong presence in the middle of the lineup. Kansas City will also rely on MJ Melendez to take the next step after an improved second half in 2024.
The bullpen is a concern for the Royals after several key arms struggled last season. James McArthur is expected to close games but may need additional help in key situations.
PPH Betting Prediction
The Royals enter this game as slight favorites at -135, while the Guardians are underdogs at +114. With Ragans showing strong form and Cleveland’s offense inconsistent, Kansas City has a slight edge. Expect a low-scoring game with strong pitching performances.
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Pick: Royals -135
